Physicians Prescription Injectable Growth Hormone Therapy, HRT > SAIZEN®:
Saizen® [somatropin
(rDNA origin) for injection] is therapeutically equivalent to the
natural GH produced by the body, made by recombinant DNA technology.
Saizen® is indicated for the treatment of Growth Hormone deficiency
in children and adults, Turner’s syndrome, chronic renal failure.
Growth Hormone treatment
of GH deficient (GHD) children with Saizen® leads to accelerated
growth. The overall effect of GH therapy in GHD children who respond
well is that, as adults, they will be taller than they would have
been if left untreated.
The role of Growth Hormone
in the human body: Growth Hormone (GH) is a protein produced by
the pituitary gland, which is situated under the hypothalamus of
the brain. This hormone controls children’s growth and regulates
a number of metabolic and physiologic processes during the whole
life. Saizen® works by replacing the Growth Hormone the body
normally produces.
Adult Growth Hormone
Deficiency at a glance
Growth deficiencies do not just affect children, they can be a significant
problem for adults too. Until recently the effects of Growth Hormone
Deficiency in adults were unknown. It is now recognized as a specific
clinical syndrome with numerous physiological consequences, with
effects on:
* Changes in body composition,
including central obesity;
* Lipids in the blood;
* Muscle strength;
* Bone composition;
* Exercise capacity an energy;
* Cardiovascular risk; and
* Psychological well-being (social isolation and depression).
In addition, there are
also studies indicating that patients with hypo-pituitarism have
an increased risk of mortality from cardiovascular disease, possibly
attributable to their GH deficiency.
GH deficiency in adults
can result from a pituitary or peri-pituitary tumor or as a direct
result of the surgery/radiation used to manage these conditions.
Less commonly GH deficiency in adults arises from a deficiency acquired
in childhood.
Adult Growth Hormone
Deficiency (AGHD) can be effectively treated recombinant human Growth
Hormone. In August 2001, Serono received approval for the use of
Saizen® in the treatment of this condition in most European
countries.
The Saizen® Device
Family: Serono is committed to simplifying treatment with Growth
Hormone. We have therefore developed a "family" of devices.
This opportunity to choose the best solution for individual patients'
needs aims to increase convenience and improve compliance with Growth
Hormone treatment.
The Saizen® Device
Family is composed of two injection devices: cool.click™ the
advanced needle-free option and one.click™, the next generation
auto injector for GH delivery. Both one.click™ and cool.click™
are for use with Saizen® 8 mg click.easy™. .
For additional product
Information. or visit: www.serono.com
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